receptors in the CA1 region of the hippocampus therefore seem to perform a conflict detection or decision-making role in the event of conflicts.
1994); glutamate stimulates NMDA
or kainite/AMPA receptors, resulting in the increase of [Ca.
But in aged neurons, the ability of PKC to anchor to the membrane becomes defective, and NMDA
receptor subunits become nonfunctional.
An alternative strategy now being explored uses gene therapy to coax rats to develop antibodies to a specific part of the NMDA
As a single isomer, d-Methadone has been shown to possess NMDA
antagonist properties with virtually no opioid activity at the expected therapeutic doses.
receptor is a commander, which is why it's called a master switch for brain cell connectivity," said Wang, the study's first author.
receptors are considered the crucial synaptic elements for the induction of activity-dependent synaptic plasticity (Collin-gridge and Singer, 1990).
It is well known that NMDA
stimulation produces increased levels of both nitric oxide and peroxynitrite (Haley et al.
receptor also plays a role in long-term potentiation (LTP), the strengthening of connections between nerve cells.
If we could find a drug that attaches itself to this site and locks together NMDA
receptor subunits, that would be huge for fighting disability from stroke and Alzheimer's and other neurodegenerative diseases," Popescu stated.
Giving up on NMDA
antagonists may be premature, however.
Studies of synaptic pruning in sensory systems have uncovered the importance of n-methyl-D-aspartate (NMDA
) receptors in differential strengthening of synapses in late maturing cortex; NMDA
leads to excess pruning, whereas NMDA
antagonists promote synaptic density (106,107).