NMDA


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AcronymDefinition
NMDAN-Methyl-D-Aspartate
NMDANew Mexico Department of Agriculture
NMDANational Marine Distributors Association
NMDANew Mexico Dressage Association
NMDANational Metal Decorators Association
NMDANational Minimum Drinking Age Act of 1984
NMDANational Missile Defense Act of 1999
References in periodicals archive ?
The NMDA receptors in the CA1 region of the hippocampus therefore seem to perform a conflict detection or decision-making role in the event of conflicts.
1994); glutamate stimulates NMDA or kainite/AMPA receptors, resulting in the increase of [Ca.
But in aged neurons, the ability of PKC to anchor to the membrane becomes defective, and NMDA receptor subunits become nonfunctional.
An alternative strategy now being explored uses gene therapy to coax rats to develop antibodies to a specific part of the NMDA receptor.
As a single isomer, d-Methadone has been shown to possess NMDA antagonist properties with virtually no opioid activity at the expected therapeutic doses.
The NMDA receptor is a commander, which is why it's called a master switch for brain cell connectivity," said Wang, the study's first author.
The NMDA receptors are considered the crucial synaptic elements for the induction of activity-dependent synaptic plasticity (Collin-gridge and Singer, 1990).
It is well known that NMDA stimulation produces increased levels of both nitric oxide and peroxynitrite (Haley et al.
The NMDA receptor also plays a role in long-term potentiation (LTP), the strengthening of connections between nerve cells.
If we could find a drug that attaches itself to this site and locks together NMDA receptor subunits, that would be huge for fighting disability from stroke and Alzheimer's and other neurodegenerative diseases," Popescu stated.
Giving up on NMDA antagonists may be premature, however.
Studies of synaptic pruning in sensory systems have uncovered the importance of n-methyl-D-aspartate (NMDA) receptors in differential strengthening of synapses in late maturing cortex; NMDA leads to excess pruning, whereas NMDA antagonists promote synaptic density (106,107).