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NNRTINon-Nucleoside Reverse Transcriptase Inhibitor
References in periodicals archive ?
All patients were receiving stavudine and at least one other NRTI and 18 patients were receiving a protease inhibitor or NNRTI.
The ability to use RDEA806 in women, without the risk of birth defects, is a major advantage over the current first-line NNRTI.
Our lead NNRTI, RDEA806, has shown the potential to match this profile and we are preparing to progress it into a Phase 2b trial later this quarter.
INTELENCE, in combination with other antiretroviral (ARV) agents, is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in antiretroviral treatment-experienced adult patients who have evidence of viral replication and HIV-1 strains resistant to a NNRTI and other ARV agents.
The traditional approval filing includes the 48-week efficacy and safety results of DUET-1 and DUET-2, two Phase 3 randomized, placebo-controlled studies that examined the use of INTELENCE in combination with other antiretroviral agents in adult treatment-experienced HIV-1 patients with documented resistance to NNRTIs and protease inhibitors.
Tipranavir Boosted With Ritonavir (TPV/r) Combined with an NNRTI Shows Superior Antiviral Activity Than TPV/r Without an NNRTI.
TMC-125, experimental NNRTI, produced 2-log HIV reduction in volunteers; [Note: "NNRTI" is an abbreviation for "non-nucleoside reverse transcriptase inhibitor," a class of anti-HIV drug.
Also, after a mean follow-up of 22 weeks, there were no differences with respect to use of an NNRTI, numbers of total and new drugs used, or numbers of drugs used to which viral resistance was detected.
We are very pleased with the continued expansion of our proprietary position in the NNRTI area.
The program comprises two randomized, placebo-controlled trials in treatment-experienced HIV-1 infected adult patients with documented NNRTI resistance and at least 3 primary protease mutations.
Two nukes and one NNRTI are now available for $100 a month--which is still out of reach of 90 percent of Africans but is no longer out of reach of 99 percent.
The Panel on Clinical Practices for the Treatment of HIV Infection recommends nevirapine as an "alternative" NNRTI.