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NNRTI |
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also found this trend in primary resistance to NNRTIs (11). based in Cork, Ireland and now part of Johnson & Johnson, is a "second generation" NNRTI (non-nucleoside reverse transcriptase inhibitor)--an antiretroviral in the same class as efavirenz (brand name Sustiva, or Stochrin in many countries) or nevirapine (Viramune). Efavirenz catapulted the NNRTI class to first-line therapy along with the PIs; its sponsor, Dupont, boldly compared efavirenz to the gold-standard PI, indinavir, in its pivotal study Dupont 006, which demonstrated that efavirenz was as potent as indinavir while being less toxic and, at once rather than 3 times daily, easier to take as well. |
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