We found an increased risk of NODAT to be significantly associated with higher body weight at the time of discharge after the transplant (Table 1).
Treatment for acute cellular rejection was found to be significantly associated with an increased risk of NODAT in this study (Table 1).
Polycystic kidneys as a cause of renal failure were also found to be significantly associated with an increased risk of NODAT in our cohort (Table 1), and several other studies have reported similar findings.
The lack of a significant association between race and NODAT in this study may be due to the disproportionately high representation of people of mixed ancestry in this cohort compared with other racial groups.
Other clinical and biochemical characteristics such as type of donor (cadaver or live), blood pressure, serum cholesterol and urine protein/ creatinine ratios were similar in the NODAT and control groups.
None of the three SNPs on the TCF7L2 gene investigated (rs11196205, rs12255372 and rs7903146) was found to be significantly associated with the risk of NODAT (Table 2).
For rs121918671, we found no significant relationship between carrying the risk allele and NODAT (Table 2).
NODAT is a common complication of renal transplantation.
Kaplan-Meier curve showing the incidence of NODAT over time.
Incidence of NODAT according to treatment arm (A = cyclosporine; B = tacrolimus).