NPDPSCNational Prion Disease Pathology Surveillance Center (Case Western Reserve University, Cleveland, OH)
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Samples of blood, urine, and CSF were sent to the NPDPSC and the Medical Research Council Prion Unit (London, UK).
The panel of diagnostic tests for CJD used for many years at the NPDPSC includes level determinations of 14-3-3 and Tau proteins in the CSF.
The availability of a national center of expertise may facilitate obtaining tissue evaluation; since the inception of NPDPSC, the number of referrals to the facility has more than doubled, from 104 in 1997 to 265 in 2002, and the number of TSE cases confirmed from those referrals increased from 60 in 1997 to 151 in 2002 (14).