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Primary viral targets for HCV include 2 enzymes: the NS3 serine protease and the NS5B RNA-dependent RNA polymerase (RdRp; "NS" refers to "non-structural protein"). In order for HCV to reproduce, NS3 must split large viral proteins into smaller, functional fragments, says Paul C. The genomic RNA is [approximately equal to] 11 kb and has 10 genes coding 3 structural proteins (capsid [C], envelope [E], and membrane [M]), and 7 nonstructural proteins (NS1, NS2a, NS2b, NS3, NS4a, NS4b, and NS5). |
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