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NZB |
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While investigating the gene sequence of a monoclonal antibody used as a marker for tumor growth, biochemist Swapan Ghosh, interim chair of the Life Sciences Department at Indiana State University, noticed that it shared 98% similarity with an antibody protein component (light chain) made by NZB mice, a popular model for autoimmune diseases. The two strains of mice used in the study, MRL-lpr and NZB W/F1, are genetically predisposed to development of symptoms of lupus disease. Effect of bisphenol A on murine immune function: modification of interferon-y, IgG2a, and disease symptoms in NZB x NZW F1 mice. |
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