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NZB/NZW

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AcronymDefinition
NZB/NZWNew Zealand Black x New Zealand White


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Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerolonephritis in NZB/NZW F1 mice.
The C5 inhibitor was administered in both an acute and rapid progressive nephritis (RPGN) model that normally leads to crescentic glomerulonephritis, the most common histologic lesion observed in patients with lupus nephritis, and also in the chronic and lethal NZB/NZW F1 lupus-prone mouse model.
Treated female NZB/NZW mice were monitored for lupus disease symptoms, defined as proteinuria (> 100 mg/dL albumin in urine for 2 consecutive weeks).
 
 
 
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