| Acronym | Definition |
|---|
| NPE | NullPointerException (Java) |
| NPE | Network Processing Engine |
| NPE | National Policy on Education |
| NPE | New Pantai Expressway (Kuala Lumpur, Malaysia) |
| NPE | National Plastics Exposition |
| NPE | Natural Penis Enlargement |
| NPE | Non-Practicing Entity (patent law) |
| NPE | Nutrition Program for the Elderly (now Nutrition Services Incentive Program) |
| NPE | Nonyl Phenol Ethoxylate |
| NPE | Network Planning and Engineering |
| NPE | Non-Paternity Event (genetic genealogy) |
| NPE | Network Protection Equipment |
| NPE | Navy Preliminary Evaluation |
| NPE | Net Premium Earned |
| NPE | Non-Permissive Environment (security) |
| NPE | Network Provider Edge |
| NPE | Negative Play Experience (games) |
| NPE | Non-Production Environment |
| NPE | Non-Person Entity (computer security) |
| NPE | Non-Polar Extractives |
| NPE | Nikon Precision Europe GmbH (Langen, Germany) |
| NPE | Nonpartisan Education Review |
| NPE | Nuclear Packing Efficiency (correlation of volume & DNA content of a cell nucleus with microscopic analysis) |
| NPE | Network Performance Endpoints (Ganynede) |
| NPE | Non-Personnel Expenditure/Expense |
| NPE | NOBL Protective Enclosure |
| NPE | National Power Equipment, Inc. (Newark, NJ) |
| NPE | National President-Elect |
| NPE | Nuclear Planning & Execution |
| NPE | NavipPlan Extended (financial planning software) |
| NPE | New Product Execution |
| NPE | Natural Power and Energy, LLC (Scottsdale, AZ) |
| NPE | Non-Public Education (North Carolina) |
| NPE | Non-Permanent Employee |
| NPE | Nonlinear Polarization Evolution |