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Figure 1 shows the retinal nerve fiber layer (RNFL) thickness in each quadrant, as measured by optical coherence tomography, for each of the patient's eyes after 9, 10, and 15 months, alongside values for historical groups of healthy subjects and of patients in an advanced stage of LHON (with atrophy of the optic nerve) (Barboni et al. Several newer diagnostic techniques are mentioned, such as scanning laser tomography, nerve fiber layer analysis, assessment of ocular perfusion, and automated perimetry methods that use color and frequency doubling. splitting of the retina, occurring in the nerve fiber layer |
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