We chose to study the TACR3 gene polymorphism rs3733631, because TACR3 endogenous ligand, neurokinin
B, by increasing blood flow (anatomoclinical feature of rosacea), is involved in the pathophysiology of (a) Parkinsonism (frequently coexists with rosacea) and (b) hot flushes in menopausal women (clinically similar to rosacea vasomotor crises).
By inhibiting the COX-2, PGE2, and tachykinin/ neurokinin
pathway, NSAIDs may decrease bladder contractility (Andersson & Hedlund, 2002; Darrah et al.
Two other tachykinin is known to exist, neurokinin
A (NKA) and neurokinin
In Chapter 10, the authors review the genetics of neurokinin
B and its receptor and their role in the regulation of human GnRH secretion in hypogonadotropic hypogonadism (HH).
In addition, researchers are evaluating the therapeutic potential of corticotrophin-releasing factor antagonists and neurokinin
1 antagonists, which may address the relationship between stress and alcohol consumption.
Evidence for the involvement of metabotropic glutamatergic, neurokinin
1 receptor pathways and protein kinase C in the antinociceptive effect of dipyrone in mice.
Chemicals such as bradykinin or neurokinin
are released at the side of the dilated vessels (Baum, Krantz, & Gatchel, 1997a).
1 receptor antagonists) offer promise for more specific and possibly more effective and long-lasting treatment efficacy.
The single neurokinin
(NK) receptor antagonist aprepitant (Emend[R]) is the newest agent (Flake et al.
It has been shown that neurokinin
B (NKB) neurons are involved in the preovulatory surge of LH and that most of NKB neurons in ARC co-localise with the estrogen receptor.
demonstrated in receptor binding assays with three neuropeptide receptors--bradykinin II expressed in Chinese hamster ovary cells, neurokinin
I expressed in astrocytoma cells, and calcitonin gene related peptide (Sampson, et al, 2000).
Effects of neurokinin
depletion on airway inflammation induced by chronic antigen exposure.