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NSE |
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CD99 and vimentin are almost always expressed in ES/PNET, while neuron-specific enolase and synaptophysin are expressed less often. Neuroendocrine markers, such as chromogranin A, neuron-specific enolase (NSE), synaptophysin, and insulin growth factor II (IGF II) are specific to pheochromocytomas and paragangliomas, and are not present in hepatocellular tumors. Clinical and demographic findings can help make distinctions, as can pertinent immunohistochemical reactions to synaptophysin, chromogranin, neuron-specific enolase (NSE), neurofilament protein (NFP), S-100 protein, keratin, CD45RB, desmin, CD99, and HMB45. |
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