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NPY |
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S-2367 is a small molecule, oral, once-daily neuropeptide Y (NPY) Y5 receptor antagonist discovered by Shionogi Research Laboratories. Nerve constriction also causes neuroplastic changes, including decreases in SP in the dorsal horn, increases in NK-1 receptor in the dorsal horn, and de novo expression of neuropeptide Y (an excitatory neuropeptide) in the dorsal root ganglion (DRG). Animal studies have indicated possible prosexual effects of Adrenocorticotropin (ACTH), a-melanocite stimulating hormone (a-MSH), and oxytocin, and adverse effects of opioid peptides, corticotropin-releasing hormone (CRF), cholecystokinin, and neuropeptide Y. |
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