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NOAELNo-Observed-Adverse-Effect Level (toxicology studies)
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In selecting a POD regulators may use the lower confidence limit of the BMD (a value abbreviated BMDL), or they may use the no-observed-adverse-effect level (NOAEL) obtained from animal experiments.
The reported no-observed-adverse-effect level (NOAEL) for fresh-pressed E.
The lowest dose was 400 times lower than the established no-observed-adverse-effect level for TFZ exposure in rodents.
These levels typically have their basis in animal data, usually the no-observed-adverse-effect level (NOAEL) from a bioassay using a limited number of test animals.
Thus, the no-observed-adverse-effect level (NOAEL) of BT products and their subfractions would correspond to doses in which there were either no spores present or there was an inhibitor (antibiotic) present to block spore-associated activity.
The EDs were estimated on the basis in levels of exposure cited in the literature as: a) With doses < 100 mg ZnSO4/Kg there is no-observed-adverse-effect levels (Noels) with respect to growth and anemia in rats; b) High levels of Zn in the diet (2000 mg/kg) is associated with an increase in resorptions and stillbirths in rats.