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It is indicated for 1) the treatment of metastatic breast cancer in women and men; 2) the treatment of node-positive breast cancer in postmenopausal women after total mastectomy or segmental mastectomy, axillary dissection, and breast irradiation; 3) the treatment of axillary node-negative breast cancer in women after total mastectomy or segmental mastectomy, axillary dissection, and breast irradiation; and 4) risk reduction in women at high risk for developing breast cancer (Table 3). Forty-three cases of node-negative breast cancer were treated at the University of Mississippi Medical Center from 1986-1992. Previous research showed that "by using uPA and PAI-1 as stratification criteria, more than one-half of all node-negative breast cancer patients can be considered to be in a low-risk patient group," she says. |
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