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A few derivatives of the known nonsteroidal antiandrogen bicalutamide (ICI 176,334) have shown androgenic effects in vitro (Dalton et al. This contention is supported by the results of an earlier study aimed at designing high-affinity nonsteroidal antiandrogens with purely antiandrogenic activity for clinical application (i. a nonsteroidal antiandrogen, used in the treatment of metastatic prostatic carcinoma. |
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