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Furthermore, histone hyperacetylation by butyrate treatment did not influence the initial levels of BPDE-DNA adducts nor did it change the rate of removal of BPDE-DNA adducts from chromatin in either normal human fibroblasts or XP fibroblasts (Kootstra 1982). The relationships between cell cycle checkpoint function and transcriptional regulation of gene expression have not been systematically studied in normal human fibroblast lines. |
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