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These uses include the physiological release of nitric oxide from the inner lining of blood vessels at a level that acts as an antioxidant as well as a suppressant of nuclear factor kappa beta, a protein which directs the inflammatory process underlying the pathology of most chronic diseases. Finally, inhibition of nuclear factor kappa beta activity in this asthmatic model with the AT-101 may have broader implications with respect to beneficial effects in other chronic inflammatory diseases. The demonstration that the AT-101 through nitric oxide release inhibits nuclear factor kappa beta activity has far reaching implications. |
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