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A classical bipartite nuclear localization signal on Thogoto and influenza A virus nucleoproteins. In the early 1990s, investigators realized that specialized proteins, given such names as transportin, importin-alpha, and importin-beta, usher proteins with a nuclear localization signal to and through nuclear pores. 2) A nuclear localization signal (NLS), present on the peptide, which directs the peptide-DNA complex into the target cell nucleus thereby promoting high-efficiency gene transfer. |
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