In addition, thymoquinone has also been shown to increase the expression of various organic anion and cation transporters such as OAT1, OAT3, OCT1, and OCT2, which are necessary for the renal clearance of xenobiotic agents including toxins and commonly used drugs [140, 141].
down arrow] urea and creatinine and MRP2 and MRP4 expression [up arrow] OAT1, OAT3, OCT1, OCT2, Nrf2, and Bcl-2 expression [up arrow] catalase, GPx, and SOD activities [down arrow] NF- [kappa]B, HSP 60 and HSP 70, and Bax expression Naringenin 7 mg/kg, [down arrow] urea, intravenous creatinine, sodium (i.
In rats, OAT1 and OAT3 have been shown to be responsible for > 60% of the renal tubular uptake of [Hg.
SNPs that were statistically significantly associated with U-Hg (MRP2, OAT1, OAT3 and LAT1) in at least one country/subgroup are presented.
23) Location/ OAT3 exposure rs4149182 subgroup CG CC p-Value Indonesia Low p (n) 0.
Polymorphisms in LAT1, OAT1, and OAT3 were associated with U-Hg, but statistically significant associations were mainly observed in Tanzania.