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Given the complexity of health endpoints and the amount of uncertainty in many models, OPPT has historically used an expert judgment/nearest-analogue approach to SARs for predicting such effects in assessing new chemicals. The OPPT has routinely used QSARs to predict ecologic hazards, fate, and risks of new industrial chemicals, as well as to identify new chemical testing needs, for more than two decades. These values, which rank chemicals in terms of their relative potency, are created especially for the model by the OPPT and are distinct from those used in traditional risk assessment. |
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