| Acronym | Definition |
|---|
| OSD | On Screen Display |
| OSD | Office of the Secretary of Defense |
| OSD | Open Software Distribution |
| OSD | Olympia School District |
| OSD | Operating System Deployment |
| OSD | Office of Supplier Diversity (Florida) |
| OSD | Open Source Definition |
| OSD | Officer on Special Duty |
| OSD | Operational System(s) Development |
| OSD | Object-Based Storage Device |
| OSD | Ohio School for the Deaf |
| OSD | Oregon School for the Deaf |
| OSD | Overseas Deployment |
| OSD | Office of Systems Development |
| OSD | Oklahoma School for the Deaf |
| OSD | Overseas Duty |
| OSD | Oral Solid Dosage (pharmaceutical use) |
| OSD | Open Source Device |
| OSD | Open Software Description format |
| OSD | On-Site Stormwater Detention (Australia) |
| OSD | One Shot Deal |
| OSD | Outside Door |
| OSD | Open Systems Development |
| OSD | Over, Short and Damaged |
| OSD | Ostersund, Sweden - Froesoe (Airport Code) |
| OSD | Optical Super Density |
| OSD | Operational Sequence Diagram |
| OSD | Operations Services Division |
| OSD | Ordered Statistic Decoding |
| OSD | Original Software Developer |
| OSD | Order of Saint Dominic |
| OSD | Openspeech Dialog |
| OSD | Ocean State Dubs (Rhode Island) |
| OSD | Operating Strength Deviation |
| OSD | Obstructive Sleep Disorder |
| OSD | Operational Specification Document |
| OSD | Operations Support Directive |
| OSD | Ordnance Supply Depot |
| OSD | Optimum Successive Decoder |
| OSD | Operating Sequence Diagram |
| OSD | Oakland School District |
| OSD | Operational Safety Document |
| OSD | Open Station Dialog (X.25) |
| OSD | Otomotiv Sanayicileri Derneði (Turkish Automotive Industrial Organization) |
| OSD | Office of the Superintendent of Detectives (Washington, DC) |
| OSD | Operating Systems Director |
| OSD | Operational Support Directive |
| OSD | Optimal Soft Decoding |
| OSD | On-Site Donations (thrift-type stores) |
| OSD | Office of Sustainable Development (various locations) |
| OSD | Ocala Service Directory |