| Acronym | Definition |
|---|
| OSC | Ontario Securities Commission |
| OSC | Office of Special Counsel |
| OSC | Oscillator |
| OSC | Ontario Science Centre (Canada) |
| OSC | Organizaciones de la Sociedad Civil (Spanish: Civil Society Organizations) |
| OSC | Orlando Science Center |
| OSC | Office of the State Controller |
| OSC | Ohio Supercomputer Center |
| OSC | Orson Scott Card (science fiction author) |
| OSC | Order to Show Cause |
| OSC | Organisations de la Société Civile (French) |
| OSC | On-Scene Coordinator |
| OSC | Oregon State College |
| OSC | One Step Closer |
| OSC | Optical Supervisory Channel |
| OSC | Optical Service Channel (Ciena) |
| OSC | Orbital Sciences Corporation |
| Osc | Oscan (linguistics) |
| OSC | On-Scene Commander |
| OSC | OpenSound Control |
| OSC | Overview and Scrutiny Committee |
| OSC | Operation Safe Commerce |
| OSC | Operations Support Center |
| OSC | Operations Section Chief |
| OSC | Oxygen Storage Capacity |
| OSC | Operations Support Command |
| OSC | Out-of-School Care |
| OSC | Office of Scholarly Communication |
| OSC | Operations Systems Center |
| OSC | Old State Capitol (Louisiana) |
| OSC | Office of Security Cooperation |
| OSC | Oxford Supercomputing Centre |
| OSC | Osteoporosis Society of Canada |
| OSC | Online Service Centre |
| OSC | Official Supporting Committee |
| OSC | Officer's Spouses' Club (USAF) |
| OSC | Optical SuperComputing (workshop) |
| OSC | Ogden Service Center |
| OSC | Open Set Condition (mathematics) |
| OSC | Office of Space Communications (NASA) |
| OSC | Oil Spill Commission |
| OSC | Objective Supply Capability |
| OSC | Office of Special Concerns (Philippines) |
| OSC | Chief Operations Specialist (US Navy) |
| OSC | operational support command (US DoD) |
| OSC | Ocean Sailing Club |
| OSC | Onshore Slug Catcher |
| OSC | Operating System Chooser |
| OSC | Oxford Soccer Club (Oxford, NC) |
| OSC | Optical Signature Code |
| OSC | Organization Structure Code |
| OSC | Optical Sensor Converter |
| OSC | Ontario Systems Corporation |
| OSC | Ocean Shipping Consultants Limited (Surrey, England) |
| OSC | Operating System Component |
| OSC | Optical Scanning Cryptography |
| OSC | Own Ship's Course |
| OSC | Own-Ship Course |
| OSC | Olympic Sports Club |
| OSC | Online Sexual Compulsivity |
| OSC | Organizational Supply Code |
| OSC | Operations Summary Console |
| OSC | Outside Speakers Committee |
| OSC | Office of Standards Compliance |
| OSC | Oneway Subjourney Check for Normal Fares (airfare construction) |
| OSC | Overseas Senior Cambridge |
| OSC | Operational Site Certification |
| OSC | Open Space Cooling System |
| OSC | Operators Services Complex |
| OSC | Optical Selective Combiner |
| OSC | Other Significant Causes (autopsy report) |
| OSC | Opportunistic Secondary Channel |
| OSC | Object Sub-class Code |
| OSC | Canons Regular of the Order of the Holy Cross, Crosier Fathers (religious order) |
| OSC | Overlapped-Subarray Correlogram |
| OSC | Operation Summary Console |
| OSC | Operations Support Call |
| OSC | Office Symbol Code |
| OSC | Organisationsberatung Supervision Coaching (German: Organizational Consulting Coaching Supervision; publication) |
| OSC | Official Supporters Club (fan clubs) |
| OSC | Outpatient Surgery Center (various locations) |
| OSC | Open Source Culture (software) |
| OSC | Operational Status Check (readiness test step, especially used for voting systems hardware) |
| OSC | Open Star Clusters (astronomy) |
| OSC | Online Support Center (various organizations) |
| OSC | Oklahoma State Cowboys (Oklahoma State University; Stillwater, OK) |
| OSC | Oakville Soccer Club (est. 1972; Oakville, Ontario, Canada) |
| OSC | Open Source Community (computing) |
| OSC | Online Support Community (various organizations) |
| OSC | Other Significant Contributor (status; various organizations) |
| OSC | Obstruent Sequencing Constraint |
| OSC | Ohio Supreme Court (judiciary) |
| OSC | Office of Science (US Department of Energy) |