| Acronym | Definition |
|---|
| OSM | Office of Surface Mining (US government) |
| OSM | Openstreetmap (free editable online world map) |
| OSM | Orchestre Symphonique de Montréal (French: Montreal Symphonic Orchestra) |
| OSM | Open Source Matters |
| OSM | Oncostatin M |
| OSM | Osmol |
| OSM | On Screen Menu |
| OSM | Oregon Steel Mills, Inc. |
| OSM | Office of Spectrum Management |
| OSM | Ons Soort Mensen (Dutch: people like us; opposite of VN) |
| OSM | Optical Switch Module |
| OSM | Operational Service Medal (UK) |
| OSM | Optical Service Module (Cisco Systems) |
| OSM | Operations Support Manager |
| OSM | Order of St. Michael (chivalric order) |
| OSM | One Square Meal (Brand) |
| OSM | Order of the Secret Monitor |
| OSM | Operating System Service Module |
| OSM | Orchid Society of Minnesota |
| OSM | Overseas Students Mission (Charlottesville, VA) |
| OSM | Object System Mapping |
| OSM | Of Smoke And Mirrors (band) |
| OSM | Oil, Smoke and Mirrors (movie on 911 and Peak Oil) |
| OSM | Output Space Mapping |
| OSM | Omni Spectra, M/A-Com (Rf Connector) |
| OSM | Oceanographic Society of Maldives |
| OSM | Off-Site Meeting |
| OSM | Order of the Servants of Mary, Servites (religious order) |
| OSM | Office Space Management |
| OSM | Office of Safety Management |
| OSM | The Original SoupMan (Staten Island, NY; est. 1984) |
| OSM | Optical Strength Meter |
| OSM | Optical Service Manager (Lucent) |
| OSM | Office of Safety and Mission Assurance (NASA) |
| OSM | Operating System Manual |
| OSM | Output Signal Management |
| OSM | Optical Selector Mechanism |
| OSM | Optical Surveillance Measure |
| OSM | Oral Satisfaction Market |
| OSM | Ordinis Servorum/Servarum Mariae (Latin: Order of Servants of Mary) |
| OSM | Operations Support Medical |
| OSM | Operating Speed Model |
| OSM | Operational Satcom Manager |
| OSM | Operating Systems and Middleware (computing) |
| OSM | On Site Management (various locations) |
| OSM | One Saturday Morning (TV program) |
| OSM | Open Study Model (Honda) |