| Acronym | Definition |
|---|
| OPM | Office of Personnel Management (US government; formerly Civil Service Commission) |
| OPM | Office of Policy and Management |
| OPM | Official Playstation Magazine |
| OPM | Original Pilipino Music |
| OPM | Operating Profit Margin (finance) |
| OPM | Object-Process Methodology |
| OPM | Office of Property Management (District of Columbia, USA) |
| OPM | Operational Performance Management (financial monitoring) |
| OPM | Office of the Program Manager |
| OPM | Open Proxy Monitor |
| OPM | Office of Program Management |
| OPM | Office of the Project Manager |
| OPM | Office of Procurement Management (GSA) |
| OPM | Optical Properties Monitor |
| OPM | Office Procedures Manual |
| OPM | Open Provenance Model (est. 2007) |
| OPM | Optimized Potential Method |
| OPM | Oh, Promise Me |
| OPM | Organisesi Papua Merdeka (Free West Papua Movement) |
| OPM | Operational Procedures Memorandum |
| OPM | FM-Operator Type M (audio synthesiser chip) |
| OPM | Oregon Productivity Matrix |
| OPM | Outage Performance Monitoring (Bellcore) |
| OPM | Obras Públicas Municipales (Guatemala) |
| OPM | Orders Per Thousand |
| OPM | Operator Programming Method |
| OPM | Openwave Provisioning Manager (Openwave Systems, Inc.) |
| OPM | Output Protection Manager (Microsoft) |
| OPM | Office of the Product Manager |
| OPM | Output and Performance Measure |
| OPM | Office of HM Paymaster General (UK) |
| OPM | On-Line Portfolio Management |
| OPM | Outpatient Pharmacy Manager |
| OPM | Operations Performance Message (NASA) |
| OPM | Onshore Plant Manager |
| OPM | Optical Processor Module |
| OPM | Ordained Pioneer Ministry/Minister (Anglican church) |
| OPM | Owning Program Manager |
| OPM | Oropharyngeal Membrane |
| OPM | Operations Management |
| OPM | Operator Performed Maintenance |
| OPM | Oracle Process Manufacturing (Oracle) |
| OPM | Overseas Port Management (Singapore) |
| OPM | Orbits Per Minute |
| OPM | Office of Pest Management (Arizona) |
| OPM | Owner's Project Manager (various organizations) |
| OPM | Orientations of Proteins in Membranes (database) |
| OPM | Optical Pass-Thru Module (IBM Corp.) |
| OPM | Out-of-Pocket Maximum (health insurance) |
| OPM | Opium |
| OPM | Outside Plant Module (telecommunications) |
| OPM | Organic Pest Management |
| OPM | Other People's Money |
| OPM | Optical Performance Monitoring (Alcatel) |
| OPM | Optical Power Meter (Bellcore) |
| OPM | Operations Per Minute |
| OPM | Optical Power Management |
| OPM | Oxygen Phone Manager (software) |
| OPM | Operations and Procedures Manual |
| OPM | Oscillations per Minute |
| OPM | Operations Message |