| Acronym | Definition |
|---|
| OSP | Oregon State Police |
| OSP | Outside Plant (telephone) |
| OSP | Office of Sponsored Programs |
| OSP | Office of Special Plans (ad hoc American intelligence agency) |
| OSP | Office of State Personnel (North Carolina) |
| OSP | Osteoporosis |
| OSP | Orbital Space Plane (NASA) |
| OSP | Open Settlement Protocol (ETSI) |
| OSP | Opportunity Scholarship Program |
| OSP | Off Street Parking |
| OSP | Organic Solderability Preservative |
| OSP | Orange Smoothie Productions (gaming) |
| OSP | Office of Science Policy (US EPA, Office of R&D) |
| OSP | Old Spanish |
| OSP | Optimum Sustainable Population |
| OSP | Official Selling Price (petroleum trading) |
| OSP | On-Line Service Provider |
| OSP | Oral Sodium Phosphate (laxative solution) |
| OSP | Oregon State Parks |
| OSP | Ohio State Patrol |
| OSP | Optical Signal Processing |
| OSP | Ochotnicza Straz Pozarna (Polish: village firebrigade) |
| OSP | Oblate Sisters of Providence |
| OSP | On Screen Programming (computer monitor) |
| OSP | Outside Processing |
| OSP | Orchid Seedbank Project (Chandler, AZ) |
| OSP | Operating Systems Principles |
| OSP | On-Site Procurement (gaming clan) |
| OSP | Ocean Survey Program |
| OSP | Offshore Procurement |
| OSP | Old Sheffield Plate (type of silver plate) |
| OSP | Operations Service Provider |
| OSP | Outside Service Provider |
| OSP | Office of Statewide Prosecution (Florida) |
| OSP | Orbital/Sub-orbital Program |
| OSP | Ocean Surveillance Product |
| OSP | Office of Scientific Personnel |
| OSP | Online Sexual Problems |
| OSP | Other Service Program |
| OSP | Operations Support Plan |
| OSP | Outside Plant Service |
| OSP | Old School Presbyterian (US census abbreviation) |
| OSP | Operational Support Package |
| OSP | Organization Standard Process |
| OSP | Obiit Sine Prole (Latin: died without issue) |
| OSP | Outside Processes |
| OSP | Okuma Sampling Path |
| OSP | Operational Security Plan |
| OSP | Optical Shared Protection |
| OSP | Offensive Stereotype Productions (website) |
| OSP | Operational Support Product |
| OSP | operations support package (US DoD) |
| OSP | Occupational Surveillance Program |
| OSP | On-Site Programmer |
| OSP | Optimal Site Path |
| OSP | Oasis Stud Poker |
| OSP | Optimized Software Process |
| OSP | Order of St. Paul the First Hermit, Pauline Fathers (religious order) |
| OSP | Operator Splitting Pre-Conditioner |
| OSP | Output Signal Processing |
| OSP | Optical Signatures Program |
| OSP | Ogden Support Page |
| OSP | Objectives & Strategies Plan |
| OSP | Open Systems Profile |