| Acronym | Definition |
|---|
| OME | Otitis Media with Effusion |
| OME | Old Man Emu (suspension systems; Park City, UT) |
| OMe | Methoxy Group |
| OME | Optical Multiservice Edge (Nortel) |
| OME | Odyssey Marine Exploration |
| OME | Open Microscopy Environment |
| OME | Observatoire Mediterraneen de l'Energie |
| OME | Office of Manpower Economics |
| OME | Osaka Mercantile Exchange |
| OME | Nome, AK, USA (Airport Code) |
| OME | Oral Motor Exercises (used in speech pathology) |
| OME | Ontario Ministry of the Environment (Canada) |
| OME | Open Messaging Environment |
| OME | Oh My Edward (movie/book Twilight) |
| OME | Oh My Edward |
| OME | Oh My Edward (Cullen) |
| OME | Oh My Edward! |
| OME | Office of Mediated Education (Kansas State University) |
| OME | Order of Magnitude Estimate |
| OME | Orbital Maneuvering Engine |
| OME | Options Made Easy |
| OME | Office of Minerals Exploration (US government) |
| OME | Oh My Emmett |
| OME | Optimal Manning Experiment (US Navy) |
| OME | Operational Mission Environment |
| OME | Original Manufacturer Equipment |
| OME | Offshore Marine Engineering (oil industry) |
| OME | Overall Machine Efficiency (paper production) |
| OME | Operational Maneuver Element (US DoD) |
| OME | Ocean Mountain Extreme (clothing label) |
| OME | Office of Management Engineer |
| OME | Oral Mechanism Examination (speech pathology) |
| OME | Ohio University College of Osteopathic Medicine (Athens, OH) |
| OME | Office of the Medical Examiner (various locations) |
| OME | Osteopathic Medical Education |