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| Acronym | Definition |
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| OSB | Oriented Strand Board | | OSB | Oracle Service Bus | | OSB | Oregon State Bar (Lake Oswego, Oregon) | | OSB | Order of Saint Benedict | | OSB | Office of the Superintendent of Bankruptcy (Canada) | | OSB | Osama Bin Laden | | OSB | One Step Beyond | | OSB | Ordinis Sancti Benedicti (of the order of St Benedict) | | OSB | Orquestra Sinfônica Brasileira (Portugese) | | OSB | Orthodox Study Bible | | OSB | Online Services Business (Microsoft business segment) | | OSB | Office Shortcut Bar (Microsoft Office) | | OSB | Office of Surveillance and Biometrics (Center for Devices and Radiological Health; US FDA) | | OSB | Offset Spoke Bed (bicycle wheels) | | OSB | Operations Support Building | | OSB | Optimization and Systems Biology (Symposium) | | OSB | Officer Selection Battery | | OSB | Operations Support Branch | | OSB | Oregon Symphonic Band (Portland, OR) | | OSB | Optimal Spectrum Balancing | | OSB | Output Signal Balance | | OSB | Other Sports Beckon | | OSB | OpenSG Binary (a 3D file format/extension) | | OSB | Overseas Service Bar | | OSB | Operational Stations Book | | OSB | Officer Selection Brief | | OSB | Old School Books | | OSB | Operation Shoe Box | | OSB | Originally Signed By | | OSB | Option Select Button | | OSB | Oberes Seitenband (German: upper sideband) | | OSB | Operation Stations Book | | OSB | Oriental Satellite Broadcasting | | OSB | Operational Service Bulletin | | OSB | Over-Determined Sub-Band | | OSB | Openshop Business | | OSB | Order of Shepherds of Bethlehem | | OSB | Official Sealed Bid (Wisconsin state procurement) | | OSB | Ortssippenbuch, Familienbuch or Ortsfamilienbuch (German) | | OSB | Office of State Budget (various locations) |
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