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Related to PAPP-A: nuchal translucency
PAPP-APregnancy-Associated Plasma Protein A
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A benchmark estimate of laboratory performance comes from comparing the results of 24 pools of patient samples distributed during the past 3 years and obtained from 36 synthetic samples (only 29 of these samples could be used for the PAPP-A analysis because of the stability issues described later).
PIGF is considered to be a marker, and PAPP-A is considered to be a potential marker, of atherosclerotic plaque instability2, 3.
PAPP-A was measured in serum by using a 1-step enzyme immunoassay based on electrochemiluminescence technology (Elecsys 2010, Roche Diagnostics).
The measurements of hCG[beta] and PAPP-A were mainly between gestational day 63 and day 95, with at least 50 samples or more per day from each center, peaking on day 77 with nearly 600 samples (see online Supplemental Table S3).
High levels of free [beta]-HCG and PAPP-A (95th percentile or higher) were not associated with an increased risk in any of the outcomes.
Serum total PAPP-A concentrations were measured with an ultrasensitive ELISA kit with polyclonal anti-PAPP-A antibody (DRG International).
Although we did not have complete outcome ascertainment, our figures are similar to those in several other studies that have recently been published showing approximately 85%-90% detection efficiency using a combination of fetal nuchal translucency, free [beta]-HCG, and PAPP-A," Mr.
Although the exact role of pregnancy-associated plasma protein A (PAPP-A) [5] in cardiac events is not fully understood, previous data imply that PAPP-A may play a role in the progression of atherosclerotic vascular disease.
Most all of the research of PAPP-A screening has been industry sponsored so far, Dr.
The presence of PAPP-A antigen in the circulation of pregnant women was first reported in 1974 (3), but it was only recently shown that PAPP-A is a metalloproteinase of the metzincin superfamily (pappalysin-1, EC 3.
NT screening combined with PAPP-A and free [beta]-HCG yielded a screen positive rate of 4.