| Acronym | Definition |
|---|
| PUP | Potentially Unwanted Program |
| PUP | Princeton University Press |
| PUP | Polytechnic University of the Philippines |
| PUP | Physically Unable to Perform (NFL player list) |
| PUP | Progressive Unionist Party |
| PUP | People's United Party (Belize) |
| PUP | PARC Universal Packet Protocol |
| PUP | Popular Unity Party (Tunisia) |
| PUP | Party for Unity and Progress (Guinea) |
| PUP | People's Unity Party (Guyana) |
| PUP | Philadelphia Unemployment Project (Philadelphia, PA) |
| PUP | Pick-Up Point |
| PUP | Personal Umbrella Policy (Liability Insurance) |
| PUP | Prevent Unwanted Pets |
| PUP | Piano Urbanistico Provinciale (Italian: Provincial Urbaistic Plan) |
| PUP | Principal User Processor (NEXRAD) |
| PUP | Private Universe Project |
| PUP | Personal Utility Pouch |
| PUP | Pirkanmaan Uusi Panimo (Finnish) |
| PUP | Play Up Pompey (The Portsmouth Chimes song) |
| PUP | Polyurethane Paint |
| PUP | Pets Uplifting People |
| PUP | Previously Untreated Patient |
| PUP | Pop Up Protector (golf) |
| PUP | Power Utility Pack (Microsoft Excel) |
| PUP | Pick-Up/Pickup |
| PUP | Princeton University Players |
| PUP | Possibly Unwanted Program (McAfee) |
| PUP | Peripheral Utility Program (Tandem) |
| PUP | Pull-Up Point |
| PUP | Portable Universal Profile |
| PUP | Pop Up Point |
| PUP | Packer Unpacker (Microsoft) |
| PUP | Product Upgrade Program (Microsoft) |
| PUP | Parang UP |
| PUP | Partido Unico de los Pendejos (Spanish) |
| PUP | Public Utility Plant |
| PUP | Pilot Upgrade Program |
| PUP | Performance Upgrade Program |
| PUP | Peripheral Unit Processor |
| PUP | Power Upgrade Program |
| PUP | Payload Utilization Plan |
| PUP | Portable Uninterruptible Power |
| PUP | Public to Public Partnership |
| PUP | Prevented Unwanted Pets (Nottingham, UK) |
| PUP | Parti de l'Unite de Populaire (Popular Unity Party, Gabon) |