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PBPK |
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Assessment of this PBPK model used additional data from the Ranch Hand cohort and a clinical report of two women exposed to TCDD. In addition, we've expanded the graphics and file output options in several ways, and improved the Virtual Trial feature when used with PBPK models. For some chemicals, human biomonitoring information can be used in combination with physiologically-based pharmacokinetic (PBPK) models to estimate dose (the success of this method depends on the properties of the environmental chemical and the availability of parameter information for building the PBPK model). |
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