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PCV7 vaccine was implemented in the NIP in November 2008 as a 3+1 dose schedule at 2, 4, 6 and 12 months.
Again, the likely recipient background for the presumed capsular switch does not appear likely to involve the 19A/ST156 lineage (Figure 2), which was well-represented during the 2000s after PCV7 implementation (6,14,32).
1, the introduction of PCV7 in SA in 2009, followed by PCV13 in 2011, led not only to a dramatic reduction in penicillin- (82%) and ceftriaxone-resistant (85%) pneumococcal infections, but also to multidrug-resistant (MDR) disease (84%).
The coverage rates of PCV7, PCV10, and PCV13 serotypes were 58.
Se ha reportado que el empleo de PCV7 logro disminuir las tasas de neumonia y enfermedad invasiva neumococica, sin embargo, existe controversia respecto a un posible aumento en la tasa de empiema en ninos vacunados, probablemente por algunas cepas emergentes como los serotipos 1, 3 y 19A.
The rates of local reactions, systemic events, and AEs observed were similar to those reported in previous trials comparing PCV13 with PCV7 given as a 3 + 1 series with routine pediatric vaccines (10, 14, 16).
In the current vaccine schedule, PCV13 is recommended for routine vaccination at ages 2, 4, and 6 months, with a booster at age 12-15 months; a single supplemental dose is recommended for children aged 14-59 months who have had an age-appropriate series of PCV7.
The PCV7 vaccine has now been replaced with a newer pneumococcal vaccine called PCV13, which works in the same way as PCV7 but protects against more strains of Streptococcus pneumoniae bacteria.
1) PCV13 is meant to replace the 7-valent PCV7 (Prevnar), and will offer protection against a wider array of pneumococcal serotypes.
10) New formulations of PCV7 and PCV11 made by the same manufacturers but covering 13 and 10 serotypes, respectively, are becoming available; one of these vaccines will probably replace PCV7 in South Africa in late 2010 or 2011.
PCV7 oncesi yapilan prevalans calismalarinda pnomokok bakteremi prevalansi %1.
You will recall that the effectiveness of PCV7 eroded over time because of the emergence of replacement strains of pneumococci that expressed different polysaccharide capsular serotypes of pneumococci than were included in PCV7.
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