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These years were chosen to validate the earlier multicenter study in the Baltimore metropolitan area (1995 and 1999) and include 1 year after licensure of PCV7 (2001). Although serotype 19F is represented in the PCV7 vaccine, it affords low levels of protection against upper respiratory infections such as otitis media (39) and has been shown recently to be the least immunogenic of the vaccine serotypes (40). |
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