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PDE4BPhosphodiesterase 4b
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sup][17],[18] Thus, it was hypothesized that targeting a single PDE4B subtype may retain efficacy but reduce the side effects of nonselective PDE4 inhibitors.
To investigate whether PDE4B regulates the expression of additional inflammatory mediators other than TNF-a and whether inhibition of PDE4B is sufficient to block these responses in macrophages, in this study we used two-dimensional (2D) gel electrophoresis to screen the secreted proteins that are modulated by the PDE4 inhibitor rolipram in LPS-stimulated Raw 264.
PDE4B is involved in controlling the negative pathway.
Since PDE4B is expressed by lung cells, we sought to determine whether inhibiting PDE4B decreased fluid accumulation during ARDS.
Two other genes--dubbed PDE4B and PKC-beta--are more active in patients in whom the lymphoma is ultimately fatal than in the other group, the researchers report.
The microarray analysis revealed significant differences in activity of NOR1, PDE4B, and PKC-beta between the two patient groups.