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PDGFR |
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of ARIAD at the Keystone Conference on Protein Kinases and Cancer: the Promise of Molecular-based Therapies shows that when tested against over 120 potential molecular targets, AP23464 selectively and potently blocks a limited number of oncogenic proteins - in addition to those previously reported (Src and Abl) - which share similar sites of molecular interaction in their drug-binding pocket, including EGFR, HER2, Raf, KIT, PDGFR and FGFR3. |
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