PECAM-1Platelet Endothelial Cell Adhesion Molecule 1
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Immunofluorescence of human PECAM-1 (A-B), mouse PECAM-1 (C-D) and mouse red blood cells (E-F) for T (left column) and ET models (right column), at 7 days.
PECAM-1 is required for transendothelial migration of leukocytes.
An autophosphorylatable band comigrating with c-Src is present in the anti-PECAM-1 immunoprecipitate, and c-Src phosphorylates and binds to a GST fusion protein containing the PECAM-1 cytoplasmic domain.
Anti-PECAM-1-antibody produces its anti-cancer effects not by binding to tumor cells, but rather by binding to PECAM-1 on the surface of normal endothelial cells that line blood vessels.
Platelet-endothelial cell adhesion molecule-1 (PECAM-1)deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane.
Among these adhesion molecules, PECAM-1 acts as a sensor of oxidative stress during the process of TEM.
PECAM-1 (CD31) is expressed on proliferating endothelial cells, stromal spindle-shaped cells, and dermal dendrocytes in Kaposi's sarcoma.
Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule.
Mixed effects on IL-8 secretion Effect of PP metabolites PP metabolites did not affect cell 3,4-dihydroxyphenyl-acetic number but sign, upregulated GSTT2 acid (ES) & 3-(3,4-dihydroxy- expression & decreased COX-2 phenyl)-propionic acid (PS) on LT97 colon cells Effect of red wine PP extract Red wine extract decreased mRNA (from Lenoir grapes) on human expression of NF-[kappa]B, ICAM-1, colon-derived CCD-18 Co VCAM-1, & PECAM-1, in a dose dependent myofibroblasts cells manner Effect of PP-rich grape seed Decreased mRNA levels of NF-[kappa]B (GS) & grape marc (CM) on target genes IL-1-3, IL-8, MCP-1 & Caco-2 cells CXCL1 in Caco-2 cells.