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Exposure of male rats to clofibrate for 3 days also results in a downregulation of PEPCK using microarrays (Gerhold et al. PEPCK or 11b-HSD1), an effect which should lessen the severity or impact of type 2 diabetes or insulin resistance. Another link between Ah receptor and PPAR functions is that both receptors influence PEPCK activity or expression [PPARs (68-70) and Ah receptor (17,71)]. |
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