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PHLPPPH domain Leucine-rich repeat Protein Phosphatase
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McKnight Brain Institute found that a recently discovered enzyme, known as PHLPP (pronounced "flip"), might be silencing a vital cell-survival protein in the region where neurons are most susceptible to damage and death.
a professor of pharmacology at the University of California, San Diego, whose team discovered PHLPP in 2005, said: "Basically, PHLPP is important in controlling whether cells survive and proliferate or die.
But if you want to stop cells that have the 'go' signal, like cancer cells, PHLPP can function as a brake.