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PIGF |
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In a normal pregnancy, PIGF promotes growth of placental blood vessels, whereas sFlt1 keeps that growth in check and halts it late in the third trimester. To further elucidate the involvement of Flt-1 in angiogenesis, researchers from ImClone Systems investigated whether specific inhibition of Flt-1 by a monoclonal antibody that blocks binding of VEGF and PIGF (placental growth factor) to Flt-1 would lead to inhibition of angiogenesis and tumor growth in mouse models. |
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