Also found in: Medical.
PIGFProvincial Inter-Governmental Forum (South Africa)
PIGFPlacental Growth Factor
References in periodicals archive ?
These cells, rather than being cytotoxic, secrete VEGF, PIGF and IL-8 [33].
The results showed that PIGF levels were far lower in pre-eclamptic patients.
The results showed that PIGF levels were dramatically lower in pre-eclamptic patients, both at the time they were ill and six to eight weeks before any symptoms appeared.
In their study of more than 1,100 patients, PIGF predicted ACS recurrences independently of markers of myocardial necrosis (such as troponin T) and markers of platelet activation (such as soluble CD40 ligand).
The investigators assessed PIGF levels in blood samples taken from 547 patients who were subjects in a large clinical trial on refractory angina and in an additional 626 consecutive patients who presented to the emergency room with acute chest pain between 1996 and 1999.
The present study was designed to test the hypothesis that in preeclampsia, excess soluble endoglin is released from the placenta into the circulation and that it may then synergize with sFlt1, which binds PIGF and vascular endothelial growth factor to cause endothelial dysfunction, he explained.
Low urinary PIGF antedates the clinical diagnosis of preeclampsia and may serve as a screening test to predict who will develop early-onset disease," Dr.
Alterations in urinary PIGF levels at 21-32 weeks were also more pronounced in women who subsequently developed preeclampsia before 37 weeks (87 pg/mL) than among those who had onset of preeclampsia at term (223 pg/mL).
Automated evaluation of angiogenic effects mediated by VEGF and PIGF homo- and heterodimers.
PIGF is a 50-kDa heterodimer consisting of 149 amino acids and has high homology with vascular endothelial growth factor (99).
About the role of PIGF, sFlt-1, sCD40L and PAPP-A in cardiovascular disease
To further elucidate the involvement of Flt-1 in angiogenesis, researchers from ImClone Systems investigated whether specific inhibition of Flt-1 by a monoclonal antibody that blocks binding of VEGF and PIGF (placental growth factor) to Flt-1 would lead to inhibition of angiogenesis and tumor growth in mouse models.