However, the reality of PINP
is different and travels well beyond those arguments.
is a specific and sensitive bone turnover marker for monitoring anabolic mode of any treatment.
At the baseline measurement, PINP
values were identical in the 49 women who subsequently developed bone metastases and the 499 women who remained metastasis-free.
The markers ICTP (intra- and interassay CVs <10%), PINP
(intra- and interassay CVs <9% and <12%, respectively), PIIINP (intra- and interassay CVs <7% and < 12%) were measured in serum by use of competitive RIAs (Orion Diagnostica) in the same assay batch.
Reduction in PINP
, a marker of bone metabolism, with raloxifine treatment and its relationship with vertebral fracture risk.
0001) than those obtained by RIA and there was a trend of increased difference between the 2 methods with increased mean PINP
BSAP, PICP and PINP
are all markers of bone formation, whereas DPD and NTX are markers of bone resorption.
Valimaki and Tahtela (11) conclude that "measurement of PINP
instead of TRACP5b is indicated for monitoring treatment with less efficacious suppressants of bone turnover.
We compared serum PINP
and TRACP5b as markers for distinguishing between responders and nonresponders to bisphosphonate treatment with alendronate or risedronate.
The IDS Rat/Mouse PINP
EIA is very flexible and measures PINP
released from collagen synthesis in rats or mice (plasma or serum).
However, the propeptides have different clearance routes, PICP being cleared by mannose receptors (2) and PINP
by scavenger receptors (3) in liver endothelial cells.
After 6 months of treatment, PINP
serum procollagen type I N-terminal propeptide, a marker of bone formation, peaked at 6 months with teriparatide by 218%; while Fosamax decreased PINP