She was found to be positive for PIV3 by viral NAAT on nasopharyngeal swab.
The BAL fluid showed PIV3 by NAAT, evidence of cytomegalovirus viral DNA, and 1,000 colony forming units/mL of Pseudomonas aeruginosa.
Compared with previously published cases of use of DAS181 for PIV3 in adult HSCT recipients (Table 1), Case 1 presented very early after transplant and failed to engraft despite growth factor stimulation which played a significant role in her early demise despite receipt of a 5-day course of DAS181.
Twenty (71%) case-patients were co-infected with other respiratory viruses, most commonly RSV B (9/28, 32%), followed by HBoV (6/28, 21%), rhinovirus V and PIV3
(4 each of 28, 14%), human metapneumovirus (3/28, 11%), adenovirus and influenza A (2 each of 28, 7%), and 229E (1/28, 4%).
Antibody responses to bovine parainfluenza virus type 3 (PIV3
) vaccination and human PIV3
infection in young infants.
TtPIV-1 is a novel virus most closely related to bovine PIV3 (BPIV-3) (4), and attenuated BPIV-3 has been demonstrated as a safe and effective vaccine against human PIV3 (HPIV-3) in human populations (34,35).
Antibody response to bovine parainfluenza virus type 3 (PIV3) vaccination and human PIV3 infection in young adults.
RT-PCR was the most sensitive diagnostic method, identifying a likely causal agent in 21 (41%) suspect SARS patients (influenza A [10 patients], HMPV [4 patients], picornavirus [4 patients], influenza B [1 patient], RSV [1 patient], and PIV3
[1 patient]) and 6 (32%) probable SARS patients (influenza A [4 patients] and HMPV [2 patients]).