PJIAPrincess Juliana International Airport
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The pathogenesis of cervical spine involvement in PJIA is synovial inflammation, hyperemia, and pannus formation at the occipitoatlantoaxial joints resulting in apophyseal joint ankylosis or fusion at C23 (vertebrae no.
Involvement of cervical spine in PJIA patients is considered a feature of poor prognosis by the American College of Rheumatology (ACR)6.
Consecutive patients of PJIA of either gender coming to Rheumatology Outpatient Department were recruited in the study after taking their consent.
Table-1: Clinical characteristics and cervical lesions observed in PJIA patients.
Ten (38%) PJIA patients with cervical symptoms and all patients without clinical signs had radiographic cervical spine involvement.
The present study was done on 50 patients of PJIA to observe radiographic involvement of cervical spine.
Previous study has shown a high prevalence of structural cervical involvement of 65% in PJIA progressing into adult life10.
CHERISH is a 104-week, phase III study in patients aged 2-17 years with active PJIA for ?