During differentiation, these cells downregulate PLZF .
Contrary to NKT1 cells, NKT2 cells are dependent on IL-17RB expression for development and express high levels of PLZF .
Deficiency of SAP and PLZF compromises the development of iNKT cells but also leads to decreases in type II NKT cell percentage .
Formalin-fixed paraffin tumor tissue was analyzed for the genes CTLA-4, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F, PLZF
, Foxp3, RORyt, CD27, and CD70.
and NPM genes in the molecular pathogenesis of acute promyelocytic leukemia.
The promyelocytic leukemia zinc-finger gene, PLZF
, is frequently downregulated in malignant mesothelioma cells and contributes to cell survival.