PLZFPromyelocytic Leukemia Zinc Finger
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During differentiation, these cells downregulate PLZF [95].
Contrary to NKT1 cells, NKT2 cells are dependent on IL-17RB expression for development and express high levels of PLZF [95].
Deficiency of SAP and PLZF compromises the development of iNKT cells but also leads to decreases in type II NKT cell percentage [115].
Formalin-fixed paraffin tumor tissue was analyzed for the genes CTLA-4, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F, PLZF, Foxp3, RORyt, CD27, and CD70.
The promyelocytic leukemia zinc-finger gene, PLZF, is frequently downregulated in malignant mesothelioma cells and contributes to cell survival.