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PPARGPeroxisome Proliferator Activated Receptor Gamma
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A slightly higher level of p53 induced PPARG and reactive oxygen species, which led the cells to differentiate into fat cells, but not bone.
Furthermore, global gene expression analysis revealed that pathways other than PPARG may also be involved in the adipogenic changes induced in differentiating human cells in response to FM550 components.
20) Recently, genes discovered to be significantly associated with developing type 2 DM, include TCF7L2, PPARG, FTO, KCNJ11, NOTCH2, WFS1, CDKAL1, IGF2BP2, SLC30A8, JAZF1, and HHEX.
724 Lizin hidroksilaz 3 PLOD3 7g36 Kalsiotropik (Steroid) Hormon/Reseptor/Enzimleri Estrojen Reseptor [alpha] ESR1 6g25,1 Estrojen Reseptor [beta] ESR2 14g23 Aromataz CYP 19 15g21,2 Androjen Reseptor AR Xg11 Glukokortikoid Reseptor GR/NR3CI 5g31 Vitamin D reseptor VDR 12g13 Vitamin D baglanma proteini DPB/GC 19gl3,3 B3-adrenerjik Reseptor ADRB3 8p12-pl1,2 Peroksizom proliferator PPARG 3p25 aktive reseptor [gamma] Kalsiyum duyarli Reseptor CASR 3g21?
cerevisiae); PPARG, peroxisome proliferator--activated receptor gamma; AKT2, v-akt murine thymoma viral oncogene homolog 2; INSR, insulin receptor; SLC30A8, solute carrier family 30 (zinc transporter), member 8; HHEX, hematopoietically expressed homeobox; CDKAL1, CDK5 regulatory subunit associated protein 1-like 1; CDKN2A, cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); CDKN2B, cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); IGF2BP2, insulin-like growth factor 2 mRNA binding protein 2; FTO, fat mass and obesity associated; JAZF1, JAZF zinc finger 1; CDC123, cell division cycle 123 homolog (S.
PPARG was reported as a candidate gene for PAD,38 because a putative functional SNP in the PPARG gene (Pro12Ala) demonstrated significant associations under the allele-contrast and dominant models.
Modulation of cytokine-induced cyclo-oxygenase 2 expression by PPARG ligands through NF-[kappa]B signal disruption in human WISH and amnion cells.
The presence of rearrangements involving the PPARG gene, PAX8/PPARG and less frequently CREB3L2/PPARG, correlates with ~95% risk of cancer, most frequently follicular variant of papillary carcinoma, followed in frequency by follicular carcinoma.
Interaction of PPARG Pro12Ala with dietary fat influences plasma lipids in subjects at cardiometabolic risk," Journal of Lipid Research, vol.
Because PPARG is so closely related to several proteins with known roles in disease, these structural insights can be applied to design new compounds for a variety of therapeutic applications.