Human, mouse and rat CAT is transcriptionally regulated by PPAR[gamma] through PPREs
containing the canonical direct repeat 1  located 12kb far from the transcription initiation site .
When we used the human adiponectin promoter bearing the mutated PPAR response element [p(-908)/LUC PPRE
mut] there were no appreciable changes in luciferase activity indicating a possible major role for PPAR-[gamma] in the activation of adiponectin promoter (Fig.
On mucosal functional tests, both EoE and PPRE
were associated with reduced transepithelial electrical resistance and lower electrical tissue impedance, most notably in patients with EoE (P less than .
Subsequently, activated PPAR/RXR heterodimers could bind to PPREs
in promoter regions of target genes.
Groups II, III, and IV were administered with PPRE
at dose levels of 375, 750, and 850 mg/kg p.
Here we have identified a novel likely obesogen, DOSS, as evidenced by PPAR[gamma] transactivation activity in a transfected cell line, activation of PPRE
in transgenic reporter mice, and induction of adipogenesis in preadipocytes in vitro.
influence insulin-sensitive genes, which enhance production of mRNAs of insulin-dependent enzymes.
PPAR alpha and PPAR gamma activators direct a distinct tissue-specific transcriptional response via a PPRE
in the lipoprotein lipase gene.
1994), with PPRE
x3-TK-luc (plasmid 1015; Addgene) (Kim et al.
Evidence for a new human CYP1A1 regulation pathway involving PPAR-atpha and 2 PPRE
In the rat, ACO responds to PPs via a functional PPRE
, whereas the equivalent gene in humans does not (31,32).