PTH-rPParathyroid Hormone Related Protein
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It is now clear that PTH-rP has a pathophysiological role not just in hypercalcemia but also in local osteolysis.
The physiological role of the PTH-rP remains unclear.
These include the effects of PTH-rP on this receptor and whether these are identical to those of PTH, whether this receptor can explain some of the controversial non-bone effects of PTH that have been described for many years such as those on the vascular system, what the signal transduction pathway that is connected to this receptor is, and finally whether this receptor is related to the anabolic response of PTH.