PUNLMPPapillary Urothelial Neoplasm of Low Malignant Potential
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Two (100%) of the patients with PUNLMPs who had follow-up data available were alive with no evidence of disease after 13 and 37 months.
In the current study, all 17 patients (100%) who were 20 years old or younger had low-grade papillary urothelial tumors, including low-grade, papillary urothelial carcinomas and PUNLMPs, whereas 13 of 42 patients (31%) who were 21 to 30 years old had high-grade urothelial carcinoma, resulting in a higher rate (31%) than that previously reported in this age group.
We plan on following the 3 young children primarily with ultrasound, but will do one surveillance cystoscopy 1-year post-resection for the 2 teenagers with the PUNLMP.
In all prior studies based on the WHO/ISUP classification, low-grade, papillary urothelial carcinoma has consistently demonstrated a recurrence rate (34%-72%) that is higher than papilloma (0%-31%) and PUNLMP (32%-51%) but lower than HG-UrCa (43%-74%).