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Both UVA irradiation and PUVA treatment induced significant changes in the distribution of arachidonic acid and increased the liberation of arachidonic acid from membrane phospholipids, with a significant increase in the formation of thiobarbituric acid-reactive material. Now, researchers have also linked PUVA to malignant melanoma, perhaps the deadliest of all skin cancers. PUVA combines the effect of the drug psoralen with exposure to ultraviolet light in the A range (UVA) to retard the speeded-up maturation and shedding of skin cells characteristic of psoriasis. |
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