Rechallenge with PZA
was previously not recommended, but a recent trial has shown that most patients tolerate it.
In patients with a baseline ALT > 120 IU/l or total bilirubin > 40 [micro]mol/l, it is recommended to start standard TB treatment and monitor closely, or to omit PZA
initially in severe cases.
kills dormant persister bacteria and plays a critical role in shortening TB therapy.
INH, RIF, PZA
, and EMB, along with moxifloxacin (MXF) and amikacin (AMK), were initiated in accordance with 2003 national TB treatment guidelines for possible MDR TB (2).
INH, isoniazid, 6 INH, 6 months isoniazid; 6-12 INH, 6-12 months INH; PZA
, Pyrazinamide; RIF, Rifampins; "Efficacy from placebo randomized trials.
The issue of CSF penetration is also unlikely because the penetration of INH and PZA
have been shown to be adequate even with a normal blood-brain barrier.
In the June 6 Nature Medicine, Ying Zhang and Angelo Scorpio of Johns Hopkins University School of Hygiene and Public Health in Baltimore report that they have identified a TB gene, pncA, that codes for an enzyme that converts the TB-fighting PZA
into an acid lethal to the bacterium.
INDIANAPOLIS & TORONTO -- When Pizza Pizza Limited (TSX: PZA
During the event, Huntkey lauched a number of new power strip series, including SZN, SZM, SZK, PZA
, PZB, PZC, PZD, SGA and PUA.
The most effective pharmacotherapy is a multidrug combination of INH, RMP, PZA
and EMB for an initial 2-month intensive treatment (initial intensive phase).
EMB and PZA
were continued for 2 months; INH and RIF were continued for 10 months (Table), at which time the patient was considered cured.
plays a unique role in shortening the duration of current TB therapy to six months and is used frequently to treat multi-drug resistant TB.