| Acronym | Definition |
|---|
| PSU | Power Supply Unit |
| PSU | Plymouth State University (Plymouth, New Hampshire) |
| PSU | Pennsylvania State University |
| PSU | Portland State University (Portland, OR USA) |
| PSU | Pittsburg State University (Pittsburg, Kansas) |
| PSU | Phantasy Star Universe (video game) |
| PSU | Playstation Universe (website) |
| PSU | Prince of Songkla University (Thailand) |
| PSU | Polysulfone |
| PSU | Playstation Underground (game) |
| PSU | Public Sector Undertaking (India; state-owned enterprises) |
| PSU | Prueba de Selección Universitaria (Spanish: University Selection Test; Chile) |
| PSU | Primary Sampling Unit |
| PSU | Port Security Unit |
| PSU | Practical Salinity Units |
| PSU | Prince Sultan University (Riyadh, Saudi Arabia) |
| PSU | Performance Share Units |
| PSU | Passenger Service Unit |
| PSU | Police Support Unit (UK police) |
| PSU | Pacific States University (Los Angeles, California) |
| PSU | Parti Socialiste Unifié (France) |
| PSU | Please Shut Up |
| PSU | Palawan State University (Philippines) |
| PSU | Prescribing Support Unit (UK) |
| PSU | Patch Set Update (Oracle) |
| PSU | Pangasinan State University (Philippines) |
| PSU | Public Service Unit |
| PSU | Pembroke State University (Lumberton, NC) |
| PSU | Power Switching Unit |
| PSU | Puntland State University (Somalia) |
| PSU | Processor Speed Up |
| PSU | Packet Switching Unit |
| PSU | Primary Support Unit |
| PSU | Primary Subordinate Unit |
| PSU | Peak Simultaneous Users |
| PSU | Plastic Surgery Company, Inc. (stock symbol; formerly the symbol for South Puerto Rico Sugar Company) |
| PSU | Professional Standard Unit |
| PSU | Postgonococcal Urethritis |
| PSU | Punjab State University (India) |
| PSU | Pressure Status Unit |
| PSU | Pulse Shaping Unit |
| PSU | Plasma Spray Unit |
| PSU | Photo-Synthetic Unit |
| PSU | Philippine Science University |
| PSU | Pressure Switch Unit |
| PSU | Pediatric Surgical Unit |
| PSU | Philadelphia Student Union (Pennsylvania) |
| PSU | Program Support Unit (various locations) |