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Pharmacokinetic/pharmacodynamic research models offer promising approaches to define the determinants of resistance selection and drug doses that optimize efficacy and reduce resistance selection. Patients will be randomized to Repinotan IIC1 or placebo in a 1:1 ratio to assess the efficacy, safety, tolerability and pharmacokinetic/pharmacodynamic effects of this drug for a total treatment period of 72 hours. Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and kepone. |
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