| Acronym | Definition |
|---|
| PLS | Please |
| PLS | Plus |
| PLS | Partial Least Squares |
| PLS | Playlist file (Real Audio file extension) |
| PLS | Plant Science |
| PLS | Palletized Load System |
| PLS | Peninsula Library System (San Mateo, CA) |
| PLS | Pohang Light Source |
| PLS | Point Last Seen (search and rescue) |
| PLS | Physical Layer Signaling |
| PLS | Physical Signaling |
| PLS | Projection to Latent Structures |
| PLS | Position Latérale de Sécurité (French: Safety Position) |
| PLS | Programmable Limit Switch |
| PLS | Pediatra di Libera Scelta (Italian: Primary Care Pediatrician) |
| PLS | Personnel Locator System |
| PLS | Plumb, Level and Square |
| PLS | Place Last Seen (search and rescue) |
| PLS | Personnel Launch System |
| PLS | Programmable Logic Sequencer |
| PLS | Physical Layer Specification |
| PLS | People's Law School (various organizations) |
| PLS | personal locator system (US DoD) |
| PLS | Partial Lump Sum |
| PLS | Position Location System |
| PLS | Private Limousine Service (various locations) |
| PLS | Pivot Legal Society (Canada) |
| PLS | Physics and Life Sciences |
| PLS | Positive Lubrication System |
| PLS | Pallet Live Storage |
| PLS | Pre-Launch Survivability |
| PLS | Professional Designation in Logistics and Supply Chain Management (American Society of Transportation and Logistics) |
| PLS | pillars of logistic support (US DoD) |
| PLS | Persian Lake States |
| PLS | Program Support Library |
| PLS | Power Leveling Sequence |
| PLS | Precautions, Limitations and Setpoints |
| PLS | Physical-Level Sharing |
| PLS | Presidential Logistics Squadron |
| PLS | Premobilization Legal Services |
| PLS | Pulsed Lepton Source |
| PLS | Product List Suppliers |
| PLS | Plans Listing Summary |
| PLS | Private Line Services (Sprint) |
| PLS | Professional Land Surveyor |
| PLS | Providenciales, Turks And Caicos Islands (Airport Code) |
| PLS | Pulse |
| PLS | Product Line Simplification |
| PLS | Princeton Law School |
| PLS | Payday Loan Store (various locations) |
| PLS | Pregnant Leach Solution (mining process) |
| PLS | Party- List System |
| PLS | Public Library of Science |
| PLS | Polska Liga Siatkowki (Polish: Polish Volleyball League) |
| PLS | Projectile Location System |
| PLS | Pre-Law Society (various schools) |
| PLS | precision location system (US DoD) |
| PLS | Public Land Survey |
| PLS | Primary Landing Site |
| PLS | Propellants and Life Support |
| PLS | Professional Legal Secretary |
| PLS | Property Listing Service (real estate) |
| PLS | Primary Lateral Sclerosis |
| PLS | Pure Live Seed |
| PLS | Profit and Loss Sharing |
| PLS | Product Launch Services |